This type of Kava is sought after by people who drink their Kava during the day and want to stay energetic and alert.Kavas high in Kavain are also ideal in social situations because it encourages talking and camaraderie.There is now little role for sedating antihistamines in allergic conditions.Less sedating antihistamines are equally efficacious. The less sedating antihistamines can be taken long term with no loss of efficacy, and an ongoing good safety profile.The sedating, first generation antihistamines now have little role in therapeutics.Their unfavourable adverse effect profile has prompted the Global Allergy and Asthma European Network to recommend making these antihistamines prescription-only, rather than over-the-counter, drugs.They are useful for treating the itching that results from the release of histamine.
In summary, we like to say that Kavas that begin with 46 are for people on the go who take their kava during the day to help with the stressful workday or social situations.
This is less of a problem with newer ‘second generation’ antihistamines, such as loratadine, and ‘third generation’ antihistamines such as desloratadine.
The oral antihistamines available in Australia to treat allergic conditions are listed in the Box.
The Kavas that start with 25 or 52 as not as popular because the highly potent dihydrokavain (DHK) and dihydromethysticin (DHM) are thought to cause nausea and lethargy.
Lebot wrote in one his papers (1) that “when the Chemotype of a Kava is rich in DHM and DHK, drinkers suffer from photophobia, diplopia and sometimes nausea.